Children's Hormone Foundation

© 2014 The Maria New Children's Hormone Foundation 
​An exempt organization qualified under section 501 C(3) of the Internal Revenue Code 



Hypertension

Dr. New discovered two forms of hormonal hypertension and cloned the genes responsible for these diseases.  In 1976, an important discovery of the cause of hypertension was made by Dr. New in a 3 year old girl. This disorder is

called Apparent Mineralocorticoid Excess (AME). The gene causing the hypertension was identified and medical treatment was designed. Dr. New has collected the largest group of patients with this form of hypertension which is

inherited. These patients come from all over the world and we have established collaborations with their local physicians to provide the long term outcome of these patients. We have discovered that these patients can be fertile despite significant high blood pressure and long term medical treatment that might interfere with fertility. The great news now is that kidney transplantation cures the disease and these patients no longer need medical treatment that interferes with fertility. This cure with kidney transplantation has now been published.

 

She continues to study low-renin hypertension of childhood as a model of hypertension, which afflicts half of the adult population in the United States and a leading cause of death.   

 

Gender

In collaboration with colleagues in psychiatry and psychoendocrinology, Dr. New continues to study the role of sex hormones in determining gender roles and behavior.  In 2010, the International Olympics Committee turned to Dr. New to assist them on this issue as it involved athletes.  

Research


Congenital Adrenal Hyperplasia (CAH)

CAH is a potentially fatal disease in the severe classical form.  The mild nonclassical form of the disease occurs with one of the highest frequencies of any genetic disorder in the world. In some ethnic groups, it occurs with particular high frequency, including Eastern European Jewish, Hispanic, Italian and Slavic populations. 

 

Patients, who have inherited a mutation from the mother and the father, suffer hormonal problems which cause impaired fertility or more severe problems. Symptoms of nonclassical CAH which is readily treatable, include severe acne, excess facial and/or body hair, early pubertal development, receding scalp hairline, menstrual irregularities in females and infertility in both males and females. 

 

The New York Times calls Dr. Maria New “the leading authority on CAH.”  She identified the disease and developed the treatments.  The Adrenal Steroid Disorders Program headed by Dr. New is the largest clinic of patients with genetic steroid disorders.  She has published her experience with 1507 families with CAH in the prestigious journal, Proceedings of the National Academy of Sciences.  


Infertility

The Foundation supports research for curing infertility.  Dr. Maria New has identified the often unrecognized but frequent cause of infertility (CAH).  She has developed the diagnostic tests to identify CAH and non-invasive, low-cost treatments that enable families to have healthy children. 


Growth

Dr. New is an authority on growth in children with steroid hormone disorders.  Research supported by the Foundation includes the use of growth hormone and other treatments in children to optimize their height.